Altered microbiota composition reflects enhanced communication in 15q11-13 CNV mice

Dian Eurike Septyaningtrias, Chia Wen Lin, Rika Ouchida, Nobuhiro Nakai, Wataru Suda, Masahira Hattori, Hidetoshi Morita, Kenya Honda, Kota Tamada, Toru Takumi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder. In addition to the core symptoms of ASD, many patients with ASD also show comorbid gut dysbiosis, which may lead to various gastrointestinal (GI) problems. Intriguingly, there is evidence that gut microbiota communicate with the central nervous system to modulate behavioral output through the gut-brain axis. To investigate how the microbiota composition is changed in ASD and to identify which microbes are involved in autistic behaviors, we performed a 16S rRNA gene-based metagenomics analysis in an ASD mouse model. Here, we focused on a model with human 15q11-13 duplication (15q dup), the most frequent chromosomal aberration or copy number variation found in ASD. Species diversity of the microbiome was significantly decreased in 15q dup mice. A combination of antibiotics treatment and behavioral analysis showed that neomycin improved social communication in 15q dup mice. Furthermore, comparison of the microbiota composition of mice treated with different antibiotics enabled us to identify beneficial operational taxonomic units (OTUs) for ultrasonic vocalization.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalNeuroscience Research
Publication statusPublished - 2020 Dec


  • Autism
  • Copy number variation
  • Gut-brain axis
  • Microbiota
  • Ultrasonic vocalization

ASJC Scopus subject areas

  • General Neuroscience


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