TY - JOUR
T1 - Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders
AU - Matsumoto, Junko
AU - Hirano, Yoshiyuki
AU - Hashimoto, Kenji
AU - Ishima, Tamaki
AU - Kanahara, Nobuhisa
AU - Niitsu, Tomihisa
AU - Shiina, Akihiro
AU - Hashimoto, Tasuku
AU - Sato, Yasunori
AU - Yokote, Koutaro
AU - Murano, Shunichi
AU - Kimura, Hiroshi
AU - Hosoda, Yutaka
AU - Shimizu, Eiji
AU - Iyo, Masaomi
AU - Nakazato, Michiko
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Comprehensive Research Project for Epidemiology, Pathology, Treatment and Outcome, Prognosis of the Patients with Eating Disorders by the Ministry of Health, Labour and Welfare, Japan and the Initiative for Realizing Diversity in the Research Environment by the Ministry of Education, Culture, Sports, Science and Technology, Japan.
Publisher Copyright:
© 2016 The Authors. Psychiatry and Clinical Neurosciences © 2016 Japanese Society of Psychiatry and Neurology
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Aim: The aims of this study were to determine whether the serum levels of precursor brain-derived neurotrophic factor (proBDNF), mature BDNF (mBDNF), and matrix metalloproteinase-9 (MMP-9) are altered in patients with eating disorders (ED), including anorexia nervosa (AN) and bulimia nervosa (BN), and to explore whether those levels are associated with decision-making abilities. Methods: Nineteen women with AN, 28 women with BN, and 22 age-matched healthy control women (HC) were enrolled in the current study. All participants had their decision-making abilities assessed using the Iowa Gambling Task (IGT). Their eating-related pathophysiology and depressive/anxiety symptoms were also evaluated. Results: The MMP-9 level in AN was significantly lower than that in either BN or HC, but the serum levels of proBDNF and mBDNF did not differ among the three groups. Investigation of the serum levels of proBDNF and MMP-9 in patients with ED and controls revealed a significant correlation between them. In the BN, there were positive correlations between mBDNF level and IGT performance and also between MMP-9 level and IGT performance, but these correlations did not occur in AN. The MMP-9 level was positively associated with the Symptom Scale, one of the subscales of the Bulimic Investigatory Test, Edinburgh, only in AN. Conclusion: These results suggest that the serum level of MMP-9 plays a role in the pathophysiology of AN, and both the serum levels of mBDNF and MMP-9 may be associated with decision-making abilities in patients with BN.
AB - Aim: The aims of this study were to determine whether the serum levels of precursor brain-derived neurotrophic factor (proBDNF), mature BDNF (mBDNF), and matrix metalloproteinase-9 (MMP-9) are altered in patients with eating disorders (ED), including anorexia nervosa (AN) and bulimia nervosa (BN), and to explore whether those levels are associated with decision-making abilities. Methods: Nineteen women with AN, 28 women with BN, and 22 age-matched healthy control women (HC) were enrolled in the current study. All participants had their decision-making abilities assessed using the Iowa Gambling Task (IGT). Their eating-related pathophysiology and depressive/anxiety symptoms were also evaluated. Results: The MMP-9 level in AN was significantly lower than that in either BN or HC, but the serum levels of proBDNF and mBDNF did not differ among the three groups. Investigation of the serum levels of proBDNF and MMP-9 in patients with ED and controls revealed a significant correlation between them. In the BN, there were positive correlations between mBDNF level and IGT performance and also between MMP-9 level and IGT performance, but these correlations did not occur in AN. The MMP-9 level was positively associated with the Symptom Scale, one of the subscales of the Bulimic Investigatory Test, Edinburgh, only in AN. Conclusion: These results suggest that the serum level of MMP-9 plays a role in the pathophysiology of AN, and both the serum levels of mBDNF and MMP-9 may be associated with decision-making abilities in patients with BN.
KW - anorexia nervosa
KW - brain-derived neurotrophic factor
KW - bulimia nervosa
KW - decision-making
KW - matrix metalloproteinase-9
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U2 - 10.1111/pcn.12490
DO - 10.1111/pcn.12490
M3 - Article
C2 - 27891714
AN - SCOPUS:85011620398
SN - 1323-1316
VL - 71
SP - 124
EP - 134
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
IS - 2
ER -
