TY - JOUR
T1 - Alu elements as an aid in deciphering genome rearrangements
AU - Toda, Yoshimi
AU - Tomita, Masaru
N1 - Funding Information:
We thank Dr Jerzy Jurka (Genetic Information Research Institute, Palo Alto, CA) and his research group for providing us with software and data on Alu elements. This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas 'Genome Science' from the Ministry of Education, Science, Sports and Culture in Japan.
PY - 1997/12/31
Y1 - 1997/12/31
N2 - Genomic rearrangements result in genomic duplications that lead to the generation of more complex genomes. Some attempts have been made to trace duplication histories of different loci using Alu elements because of their large population in primate genomes. In this short report, using the human growth hormone locus as an example, we demonstrate the usefulness of Alu repetitive elements in computer sequence analyses when tracing duplication histories. Information on subfamily classification, direction, arrangements, Poly(A) tails and direct repeats can aid our understanding of genome rearrangements.
AB - Genomic rearrangements result in genomic duplications that lead to the generation of more complex genomes. Some attempts have been made to trace duplication histories of different loci using Alu elements because of their large population in primate genomes. In this short report, using the human growth hormone locus as an example, we demonstrate the usefulness of Alu repetitive elements in computer sequence analyses when tracing duplication histories. Information on subfamily classification, direction, arrangements, Poly(A) tails and direct repeats can aid our understanding of genome rearrangements.
KW - Computer
KW - Direct repeat
KW - Evolutionary distance
KW - Poly(A) tail
KW - Sequence evolution
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U2 - 10.1016/S0378-1119(97)00541-6
DO - 10.1016/S0378-1119(97)00541-6
M3 - Article
C2 - 9461391
AN - SCOPUS:0031593158
SN - 0378-1119
VL - 205
SP - 173
EP - 176
JO - Gene
JF - Gene
IS - 1-2
ER -