An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Satoka Nagai; Yuka Yamagishi; Yuta Shimizu; Ken Ichi Takao; Kin Ichi Tadano

doi:10.3987/COM-14-S(K)55

An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Satoka Nagai, Yuka Yamagishi, Yuta Shimizu, Ken Ichi Takao, Kin Ichi Tadano

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The construction of the 13-membered para-cyclophane substructure in GKK1032As, a member of novel pyrrolidinone-containing bioactive natural products, has been explored. An efficient approach for this synthetically formidable object was found, which relied on an intramolecular 1,4-addition between a nitromethylene group and a vinyl ketone moiety both incorporated as side chains into the 6/5/6-tricyclic (the A/B/C-ring system) of the GKK1032s.

Original language	English
Pages (from-to)	819-826
Number of pages	8
Journal	Heterocycles
Volume	90
Issue number	2
DOIs	https://doi.org/10.3987/COM-14-S(K)55
Publication status	Published - 2015

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "The construction of the 13-membered para-cyclophane substructure in GKK1032As, a member of novel pyrrolidinone-containing bioactive natural products, has been explored. An efficient approach for this synthetically formidable object was found, which relied on an intramolecular 1,4-addition between a nitromethylene group and a vinyl ketone moiety both incorporated as side chains into the 6/5/6-tricyclic (the A/B/C-ring system) of the GKK1032s.",

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AU - Nagai, Satoka

AU - Yamagishi, Yuka

AU - Shimizu, Yuta

AU - Takao, Ken Ichi

AU - Tadano, Kin Ichi

PY - 2015

Y1 - 2015

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AB - The construction of the 13-membered para-cyclophane substructure in GKK1032As, a member of novel pyrrolidinone-containing bioactive natural products, has been explored. An efficient approach for this synthetically formidable object was found, which relied on an intramolecular 1,4-addition between a nitromethylene group and a vinyl ketone moiety both incorporated as side chains into the 6/5/6-tricyclic (the A/B/C-ring system) of the GKK1032s.

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An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Abstract

ASJC Scopus subject areas

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