An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Root of Astragalus mongholicus

Noriko Shimizu; Masashi Tomoda; Mieko Kanari; Ryōko Gonda

doi:10.1248/cpb.39.2969

An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Root of Astragalus mongholicus

Noriko Shimizu, Masashi Tomoda, Mieko Kanari, Ryōko Gonda

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus bunge. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 10⁴. It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of u-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of 0-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly a-arabino-β-3,6-galactan type structural units.

Original language	English
Pages (from-to)	2969-2972
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	39
Issue number	11
DOIs	https://doi.org/10.1248/cpb.39.2969
Publication status	Published - 1991

Keywords

Astragalus mongholicus
acidic arabinogalactan
immunological activity
polysaccharide structure
reticuloendothelial system

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.39.2969

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abstract = "An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus bunge. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 104. It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of u-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of 0-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly a-arabino-β-3,6-galactan type structural units.",

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AU - Gonda, Ryōko

PY - 1991

Y1 - 1991

N2 - An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus bunge. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 104. It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of u-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of 0-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly a-arabino-β-3,6-galactan type structural units.

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An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Root of Astragalus mongholicus

Abstract

Keywords

ASJC Scopus subject areas

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