Enterprises and information societies confront crucial challenges currently, while Industry 4.0 becomes important in the global manufacturing industry and Society 5.0 should contribute to a supersmart society, especially for healthcare. Physical activity monitoring digital platforms are architected to improve the healthcare status of patients with diabetes and other lifestyle-related diseases. Furthermore, digital platforms are expected to generate profits for health technology companies and help control costs in the healthcare ecosystem. However, current digital enterprise architecture approaches are not well-established, and the potentials have not yet been realized. Design thinking approach and agile software development methodologies can overcome these limitations, beginning with proof of concept and pilot projects and then scaling to the production environment. In this paper, we describe how that the adaptive integrated digital architecture framework (AIDAF) for Design Thinking approach is proposed and verified in a case of a university hospital in the Americas. In addition, challenges and future activities for this area are discussed that cover the directions for Society 5.0.