Abstract
Hypersensitivity to mosquito bites (HMB) has been known to occur exclusively in the first 2 decades of life and is frequently associated with Epstein-Barr virus (EBV) infection and lymphoproliferative diseases. We report here the first adult patient with HMB, a 61-year-old Japanese man who developed mantle cell lymphoma. EBV was detected in the lymph node by polymerase chain reaction and by in situ hybridization. Serum levels of interleukin (IL)-4, IL-6, and IL-10 were markedly increased, and the T-helper cell (Th)1/Th2 balance determined by intracellular cytokine levels was polarized to Th2. These findings suggest that the Th1/Th2 imbalance could partly be involved in the pathogenesis of HMB.
| Original language | English |
|---|---|
| Pages (from-to) | 259-262 |
| Number of pages | 4 |
| Journal | International journal of hematology |
| Volume | 71 |
| Issue number | 3 |
| Publication status | Published - 2000 |
| Externally published | Yes |
Keywords
- Epstein-barr virus
- Hypersensitivity to mosquito bites
- Mantle cell lymphoma
- T-helper cell (Th)1/Th2 balance
ASJC Scopus subject areas
- Hematology