An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme

Shota Sotokawa; Takashi Kitamura; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/c8cc06130k

An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme

Shota Sotokawa, Takashi Kitamura, Daisuke Takahashi, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.

Original language	English
Pages (from-to)	10614-10617
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	75
DOIs	https://doi.org/10.1039/c8cc06130k
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc06130k

Cite this

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title = "An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme",

abstract = "A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.",

author = "Shota Sotokawa and Takashi Kitamura and Daisuke Takahashi and Kazunobu Toshima",

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AU - Sotokawa, Shota

AU - Kitamura, Takashi

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2018

Y1 - 2018

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AB - A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.

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JO - Chemical Communications

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ER -

An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme

Abstract

ASJC Scopus subject areas

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