An autopsy case of unresectable colon cancer who developed lung injury by cetuximab

Junko Uemoto; Yasuo Hamamoto; Kei Onodera; Tomohiro Nishi; Etsuko Warita; Yasuhiro Yamanaka; Nobuo Hoshi; Kaoru Hirabayashi; Sayuri Hoshi; Seiji Igarashi

An autopsy case of unresectable colon cancer who developed lung injury by cetuximab

Junko Uemoto, Yasuo Hamamoto, Kei Onodera, Tomohiro Nishi, Etsuko Warita, Yasuhiro Yamanaka, Nobuo Hoshi, Kaoru Hirabayashi, Sayuri Hoshi, Seiji Igarashi

Oncology Center

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We report the case of a woman in her 60s with unresectable advanced colon cancer. After the first course of cetuximab as second-line therapy, she had developed drug-induced lung injury. Steroid pulse therapy had been ineffective, and she died of respiratory failure on day 9. The pathological examination of autopsy lung specimens revealed diffuse alveolar damage (DAD). Details of the cetuximab-induced lung injury are unclear. However, in 3 previous reports of lung injury by cetuximab, the postmortem findings were similar to this case. We concluded that DAD seems to be one of the pathological features of lung injury caused by cetuximab.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	40
Issue number	2
Publication status	Published - 2013 Feb

Keywords

Cetuximab
Colorectal cancer
Diffuse alveolar damage

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "We report the case of a woman in her 60s with unresectable advanced colon cancer. After the first course of cetuximab as second-line therapy, she had developed drug-induced lung injury. Steroid pulse therapy had been ineffective, and she died of respiratory failure on day 9. The pathological examination of autopsy lung specimens revealed diffuse alveolar damage (DAD). Details of the cetuximab-induced lung injury are unclear. However, in 3 previous reports of lung injury by cetuximab, the postmortem findings were similar to this case. We concluded that DAD seems to be one of the pathological features of lung injury caused by cetuximab.",

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AU - Uemoto, Junko

AU - Hamamoto, Yasuo

AU - Onodera, Kei

AU - Nishi, Tomohiro

AU - Warita, Etsuko

AU - Yamanaka, Yasuhiro

AU - Hoshi, Nobuo

AU - Hirabayashi, Kaoru

AU - Hoshi, Sayuri

AU - Igarashi, Seiji

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N2 - We report the case of a woman in her 60s with unresectable advanced colon cancer. After the first course of cetuximab as second-line therapy, she had developed drug-induced lung injury. Steroid pulse therapy had been ineffective, and she died of respiratory failure on day 9. The pathological examination of autopsy lung specimens revealed diffuse alveolar damage (DAD). Details of the cetuximab-induced lung injury are unclear. However, in 3 previous reports of lung injury by cetuximab, the postmortem findings were similar to this case. We concluded that DAD seems to be one of the pathological features of lung injury caused by cetuximab.

AB - We report the case of a woman in her 60s with unresectable advanced colon cancer. After the first course of cetuximab as second-line therapy, she had developed drug-induced lung injury. Steroid pulse therapy had been ineffective, and she died of respiratory failure on day 9. The pathological examination of autopsy lung specimens revealed diffuse alveolar damage (DAD). Details of the cetuximab-induced lung injury are unclear. However, in 3 previous reports of lung injury by cetuximab, the postmortem findings were similar to this case. We concluded that DAD seems to be one of the pathological features of lung injury caused by cetuximab.

KW - Cetuximab

KW - Colorectal cancer

KW - Diffuse alveolar damage

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An autopsy case of unresectable colon cancer who developed lung injury by cetuximab

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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