An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization

Naoya Kumagai, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


A real step-saver! In a one-step procedure for the synthesis of bicyclic amidines, the azido group is used directly as the nucleophile in the ring-forming reaction. Many functionalized and chiral bicyclic amidines were synthesized in good yield under mild reaction conditions.

Original languageEnglish
Pages (from-to)478-482
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number4
Publication statusPublished - 2004 Jan 16
Externally publishedYes


  • Azides
  • Chirality
  • Cyclization
  • Nitrogen heterocycles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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