An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization

Naoya Kumagai; Shigeki Matsunaga; Masakatsu Shibasaki

doi:10.1002/anie.200352750

An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization

Naoya Kumagai, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A real step-saver! In a one-step procedure for the synthesis of bicyclic amidines, the azido group is used directly as the nucleophile in the ring-forming reaction. Many functionalized and chiral bicyclic amidines were synthesized in good yield under mild reaction conditions.

Original language	English
Pages (from-to)	478-482
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	4
DOIs	https://doi.org/10.1002/anie.200352750
Publication status	Published - 2004 Jan 16
Externally published	Yes

Keywords

Azides
Chirality
Cyclization
Nitrogen heterocycles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200352750

Cite this

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abstract = "A real step-saver! In a one-step procedure for the synthesis of bicyclic amidines, the azido group is used directly as the nucleophile in the ring-forming reaction. Many functionalized and chiral bicyclic amidines were synthesized in good yield under mild reaction conditions.",

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AU - Shibasaki, Masakatsu

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KW - Chirality

KW - Cyclization

KW - Nitrogen heterocycles

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An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization

Abstract

Keywords

ASJC Scopus subject areas

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