An expeditious route to GlcNAc-Cbz-Asn by chemo-enzymatic synthesis

Y. Tokuda, Y. Takahashi, K. Matoishi, Y. Ito, T. Sugai

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A short-step route to GlcNAc-Cbz-Asn was developed. Treatment of GlcNAc in sat. aq. NH4HCO3 solution and subsequent electorodialytic desalting provided ammonia-free glycosylamine in large quantity. The product was coupled with Cbz-Asn α-isobutyl ester β-fluoride, and finally, the isobutyl ester was deprotected by enzyme-catalyzed hydrolysis under mild conditions.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
Issue number1
Publication statusPublished - 2002


  • Amino acids
  • Coupling
  • Enzymes
  • Glycosides
  • Hydrolyses

ASJC Scopus subject areas

  • Organic Chemistry


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