An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides

Seiya Katahara, Shoichiro Kobayashi, Kanami Fujita, Tsutomu Matsumoto, Takaaki Sato, Noritaka Chida

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)


An Ir-catalyzed reductive formation of functionalized nitrones from N-hydroxyamides was reported. The reaction took place through two types of iridium-catalyzed reactions including dehydrosilylation and hydrosilylation. The method showed high chemoselectivity in the presence of sensitive functional groups, such as methyl esters, and was successfully applied to the synthesis of cyclic and macrocyclic nitrones, which are known to be challenging compounds to access by conventional methods. 1H NMR studies strongly supported generation of an N-siloxyamide and an N,O-acetal as the actual intermediates.

Original languageEnglish
Pages (from-to)5246-5249
Number of pages4
JournalJournal of the American Chemical Society
Issue number16
Publication statusPublished - 2016 Apr 27

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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