Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

T. Sato; H. Nishi; Y. Okahata; Y. Shoji; J. Shimada

Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

T. Sato, H. Nishi, Y. Okahata, Y. Shoji, J. Shimada

Research output: Contribution to journal › Article › peer-review

Abstract

We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

Original language	English
Pages (from-to)	303-304
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	37
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Analysis for the subcellular distribution of oligonucleotide/lipid complexes.",

abstract = "We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.",

author = "T. Sato and H. Nishi and Y. Okahata and Y. Shoji and J. Shimada",

year = "1997",

language = "English",

pages = "303--304",

journal = "Nucleic acids symposium series",

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publisher = "Information Retrieval",

number = "37",

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AU - Sato, T.

AU - Nishi, H.

AU - Okahata, Y.

AU - Shoji, Y.

AU - Shimada, J.

PY - 1997

Y1 - 1997

N2 - We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

AB - We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

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M3 - Article

C2 - 9586120

AN - SCOPUS:0031318520

SN - 0261-3166

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EP - 304

JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

IS - 37

ER -

Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

Abstract

ASJC Scopus subject areas

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