Analysis on nonspherical oscillation of microbubble with two-dimensional numerical fluid simulation

Hiroki Kubo, Akira Tsuruoka, Kei Terada, Toshihiko Sugiura

Research output: Contribution to journalArticlepeer-review


Recently, ultrasound contrast imaging has been improved greatly, because its application of an approach for therapy is urgently required for area of the heart and abdominal. Sonoporation is also one of the applications using microbubbles that attracts attention in the world. There have been so many studies for understanding the mechanism of sonoporation and improving efficiency of ultrasound contrast agents. Nonspherical oscillation is at a stage before the breakup process of microbubbles. Therefore, consideration of a microbubble's nonspherical oscillation is absolutely imperative for its future development. Thus in this thesis, the author regarded microbubbles as two dimensional air-liquid two-phase flow and calculated their dynamics by using Computational Fluid Dynamics (CFD). Numerical calculation of a microbubble's oscillation and deformation was also carried out, for an air bubble and for a shell-coated bubble in ultrasound field. As a result, it was confirmed that the CFD method developed in this study can be useful for analyzing an insonified microbubble showing nonspherical oscillation.

Original languageEnglish
Pages (from-to)1327-1335
Number of pages9
JournalNihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
Issue number801
Publication statusPublished - 2013
Externally publishedYes


  • Computational fluid dynamics
  • Contrast agents
  • Forced vibration
  • Gas-liquid two-phase flow
  • Lipid shell
  • Micro-bubble
  • Nonlinear oscillation
  • Ultrasound

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering


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