Anesthesia for total hip arthroplasty in a patient with C1 inhibitor deficiency

Tomoko Oyaizu, Aya Kikuchi, Rie Minoshima, Hiromasa Nagata, Hironori Sakurai, Takeshi Suzuki, Nobuyuki Katori, Hiroshi Morisaki

Research output: Contribution to journalArticlepeer-review


C1 inhibitor (INH) deficiency is characterized by the presence of angioedema of the extremities, face, airway and the gastrointestinal tract. Airway obstruction is the most common cause of mortality. A 78-year-old woman presented with repeated episodes of angioedema. These episodes were triggered by general anesthesia, dental extraction, venipuncture, vaccination and loxoprofen. The familiy history of similar symptoms was negative. C1 inhibitor concentrate was administered perioperatively for prophylaxis of attacks. Operation was performed under neurolept anesthesia and combined spinal-epidural anesthesia in order to avoid airway manipulation. Postoperative pain was controlled by patient-controlled epidural anesthesia to prevent attacks triggered by pain. The patient had angioedema on both lower extremities perioperatively but did not develop further attacks. Anesthesia was safely performed in a patient with C1 inhibitor deficiency scheduled for total hip arthroplasty.

Original languageEnglish
Pages (from-to)820-822
Number of pages3
JournalJapanese Journal of Anesthesiology
Issue number7
Publication statusPublished - 2014 Jul


  • Airway management
  • Airway obstruction
  • Angioedema
  • C1 inhibitor deficiency

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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