Angiogenesis and its therapeutic implication. 5. Bone marrow angiogenesis and anti-angiogenic therapy in multiple myeloma

Yutaka Hattori

doi:10.2169/internalmedicine.42.303

Angiogenesis and its therapeutic implication. 5. Bone marrow angiogenesis and anti-angiogenic therapy in multiple myeloma

Yutaka Hattori

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

In summary, increased bone marrow MVD as well as plasma concentrations of angiogenic growth factors are correlated with disease activity in MM. These results suggest that bone marrow angiogenesis may be an important factor for disease progression and can also be a therapeutic target. Thalidomide, known as an inhibitor of angiogenesis, was effective for the treatment of refractory MM. However, special caution must be paid to it's adverse effects.

Original language	English
Pages (from-to)	303-305
Number of pages	3
Journal	Internal Medicine
Volume	42
Issue number	3
DOIs	https://doi.org/10.2169/internalmedicine.42.303
Publication status	Published - 2003 Mar 1

Keywords

Angiogenic growth factors
Multiple myeloma
Thalidomide
Tumor angiogenesis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.42.303

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abstract = "In summary, increased bone marrow MVD as well as plasma concentrations of angiogenic growth factors are correlated with disease activity in MM. These results suggest that bone marrow angiogenesis may be an important factor for disease progression and can also be a therapeutic target. Thalidomide, known as an inhibitor of angiogenesis, was effective for the treatment of refractory MM. However, special caution must be paid to it's adverse effects.",

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AB - In summary, increased bone marrow MVD as well as plasma concentrations of angiogenic growth factors are correlated with disease activity in MM. These results suggest that bone marrow angiogenesis may be an important factor for disease progression and can also be a therapeutic target. Thalidomide, known as an inhibitor of angiogenesis, was effective for the treatment of refractory MM. However, special caution must be paid to it's adverse effects.

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KW - Tumor angiogenesis

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Angiogenesis and its therapeutic implication. 5. Bone marrow angiogenesis and anti-angiogenic therapy in multiple myeloma

Abstract

Keywords

ASJC Scopus subject areas

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