Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in urogenital cancer

Akira Miyajima; Eiji Kikuchi; Takeo Kosaka; Mototsugu Oya

doi:10.2174/157488709788185996

Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in urogenital cancer

Akira Miyajima, Eiji Kikuchi, Takeo Kosaka, Mototsugu Oya

Department of Urology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The potential for angiotensin II (AII) to promote tumor growth has been suspected based on its known hormonal actions and its vasoconstrictor effect. It has been suggested that angiotensin-converting enzyme (ACE) inhibitors may offer protection against cancer and may prevent carcinogenesis. Several studies report that AII can induce neovascularization in experimental systems by way of the AII type 1 receptor (AT1R). AT1R is also frequently expressed in such human tumors as skin cancer, renal cell carcinoma, and breast cancer. A growing number of recent studies focusing on treatment with an AT1R antagonist have demonstrated that angiotensin receptor blockade (ARB) appears to inhibit not only the growth of cancer cells but also tumor angiogenesis. We describe here the effects of AT1R blockade that implicate tumor angiogenesis in urogenital cancer since ARB may be an alternative modality for anti-cancer treatment.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Reviews on Recent Clinical Trials
Volume	4
Issue number	2
DOIs	https://doi.org/10.2174/157488709788185996
Publication status	Published - 2009

Keywords

Angiogenesis
Angiotensin
Bladder
Kidney
Prostate
Receptor

ASJC Scopus subject areas

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/157488709788185996

Cite this

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abstract = "The potential for angiotensin II (AII) to promote tumor growth has been suspected based on its known hormonal actions and its vasoconstrictor effect. It has been suggested that angiotensin-converting enzyme (ACE) inhibitors may offer protection against cancer and may prevent carcinogenesis. Several studies report that AII can induce neovascularization in experimental systems by way of the AII type 1 receptor (AT1R). AT1R is also frequently expressed in such human tumors as skin cancer, renal cell carcinoma, and breast cancer. A growing number of recent studies focusing on treatment with an AT1R antagonist have demonstrated that angiotensin receptor blockade (ARB) appears to inhibit not only the growth of cancer cells but also tumor angiogenesis. We describe here the effects of AT1R blockade that implicate tumor angiogenesis in urogenital cancer since ARB may be an alternative modality for anti-cancer treatment.",

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AU - Miyajima, Akira

AU - Kikuchi, Eiji

AU - Kosaka, Takeo

AU - Oya, Mototsugu

PY - 2009

Y1 - 2009

N2 - The potential for angiotensin II (AII) to promote tumor growth has been suspected based on its known hormonal actions and its vasoconstrictor effect. It has been suggested that angiotensin-converting enzyme (ACE) inhibitors may offer protection against cancer and may prevent carcinogenesis. Several studies report that AII can induce neovascularization in experimental systems by way of the AII type 1 receptor (AT1R). AT1R is also frequently expressed in such human tumors as skin cancer, renal cell carcinoma, and breast cancer. A growing number of recent studies focusing on treatment with an AT1R antagonist have demonstrated that angiotensin receptor blockade (ARB) appears to inhibit not only the growth of cancer cells but also tumor angiogenesis. We describe here the effects of AT1R blockade that implicate tumor angiogenesis in urogenital cancer since ARB may be an alternative modality for anti-cancer treatment.

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KW - Bladder

KW - Kidney

KW - Prostate

KW - Receptor

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Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in urogenital cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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