TY - JOUR
T1 - Anti-Markovnikov Addition of Anilines to Aliphatic Terminal Alkynes Catalyzed by an 8-Quinolinolato Rhodium Complex
AU - Morimoto, Yoshihiko
AU - Kochi, Takuya
AU - Kakiuchi, Fumitoshi
N1 - Funding Information:
. thanks to financial support, in part, by the Japanese Society for the Promotion of Science (JSPS) Grant‐in‐Aid for Scientific Research JP21H01944, Japan, and JST CREST Grant Number JPMJCR20R1. . is grateful for support by the Research Grant of Keio Leading‐edge Laboratory of Science & Technology and Research Grant of Keio Research Development and Sponsored Projects, Faculty of Science & Technology. F. K Y. M
Funding Information:
F. K. thanks to financial support, in part, by the Japanese Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research JP21H01944, Japan, and JST CREST Grant Number JPMJCR20R1. Y. M. is grateful for support by the Research Grant of Keio Leading-edge Laboratory of Science & Technology and Research Grant of Keio Research Development and Sponsored Projects, Faculty of Science & Technology.
Publisher Copyright:
© 2021 Wiley-VHCA AG, Zurich, Switzerland
PY - 2021/10
Y1 - 2021/10
N2 - Anti-Markovnikov addition of anilines to aliphatic terminal alkynes proceeded using an 8-quinolinolato rhodium/phosphine catalyst system. The use of a strong organic base, 1,1,3,3,–tetramethylguanidine, in the catalyst system enabled the formation of the aldimine products. Substrates with various functional groups including polar groups such as a phenolic hydroxy group are applicable to the hydroamination.
AB - Anti-Markovnikov addition of anilines to aliphatic terminal alkynes proceeded using an 8-quinolinolato rhodium/phosphine catalyst system. The use of a strong organic base, 1,1,3,3,–tetramethylguanidine, in the catalyst system enabled the formation of the aldimine products. Substrates with various functional groups including polar groups such as a phenolic hydroxy group are applicable to the hydroamination.
KW - 8-quinolinolate ligand
KW - aldimines
KW - aliphatic terminal alkynes
KW - alkynes
KW - anilines
KW - anti-Markovnikov addition
KW - rhodium
UR - http://www.scopus.com/inward/record.url?scp=85115838824&partnerID=8YFLogxK
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U2 - 10.1002/hlca.202100125
DO - 10.1002/hlca.202100125
M3 - Article
AN - SCOPUS:85115838824
SN - 0018-019X
VL - 104
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 10
M1 - e2100125
ER -