Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Ulises G. Castillo, Yoshinori Uekusa, Takehiro Nishimura, Fumiyuki Kiuchi, Morena L. Martínez, Jenny Menjívar, Junko Nakajima-Shimada, Marvin J. Núñez, Haruhisa Kikuchi

Research output: Contribution to journalArticlepeer-review

Abstract

A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.

Original languageEnglish
Pages (from-to)1067-1074
Number of pages8
JournalJournal of Natural Products
Volume87
Issue number4
DOIs
Publication statusPublished - 2024 Apr 26

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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