Anti-trypanosomal screening of Salvadoran flora

Ulises G. Castillo, Ayato Komatsu, Morena L. Martínez, Jenny Menjívar, Marvin J. Núñez, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi, Junko Nakajima-Shimada

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4 Citations (Scopus)


Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and in Central America, it is considered one of the four most infectious diseases. This study aimed to screen the anti-trypanosomal activity of plant species from Salvadoran flora. Plants were selected through literature search for plants ethnobotanically used for antiparasitic and Chagas disease symptomatology, and reported in Museo de Historia Natural de El Salvador (MUHNES) database. T. cruzi was incubated for 72 h with 2 different concentrations of methanolic extracts of 38 species, among which four species, Piper jacquemontianum, Piper lacunosum, Trichilia havanensis, and Peperomia pseudopereskiifolia, showed the activity (≤ 52.0% viability) at 100 µg/mL. Separation of the methanolic extract of aerial parts from Piper jacquemontianum afforded a new flavanone (4) and four known compounds, 2,2-dimethyl-6-carboxymethoxychroman-4-one (1), 2,2-dimethyl-6-carboxychroman-4-one (2), cardamomin (3), and pinocembrin (5), among which cardamomin exhibited the highest anti-trypanosomal activity (IC50 = 66 µM). Detailed analyses of the spectral data revealed that the new compound 4, named as jaqueflavanone A, was a derivative of pinocembrin having a prenylated benzoate moiety at the 8-position of the A ring. Graphic abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - 2022 Jan


  • Chagas disease
  • Flavonoids
  • Piper jacquemontianum
  • Salvadoran flora
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Molecular Medicine


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