TY - JOUR
T1 - Antibacterial activity of norfloxacin on methicillin-resistant staphylococcus aureus
AU - Iwata, Satoshi
AU - Kawashima, Chieko
AU - Sakamoto, Haruo
AU - Isohata, Eiichi
AU - Kin, Yoshiaki
AU - Yokota, Takao
AU - Kusumoto, Yutaka
AU - Sato, Yoshitake
AU - Akita, Hironobu
AU - Oikawa, Tadao
AU - Sunakawa, Keisuke
PY - 1990
Y1 - 1990
N2 - Minimum inhibitory concentrations (MIC) of norfloxacin (NFLX) to 133 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical patients were investigated and compared with those of minocycline (MINO), erythromycin (EM), amoxicillin (AMPC), cefaclor (CCL) and fosfomycin (FOM). MIC90 of these drugs were 3.13 μg/ml with NFLX, 0.39 μg/ml with MINO, >100 μg/ml with EM, 50 μg/ml with AMPC, >100 μg/ml with CCL and >100 μg/ml with FOM. MIC distribution patterns with 2 peaks were recognized with EM and FOM. Of 55 strains resistant to all of EM, AMPC, CCL and FOM, 50 and 54 strains were well susceptible to NFLX and MINO, respectively. The present investigation demonstrated relatively potent antibiotic effect of NFLX against MRSA. Considering the safety of NFLX to children which have been confirmed and reported separately, it can be concluded that NFLX is a useful oral antimicrobial drug in the treatment of children with MRSA infections.
AB - Minimum inhibitory concentrations (MIC) of norfloxacin (NFLX) to 133 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical patients were investigated and compared with those of minocycline (MINO), erythromycin (EM), amoxicillin (AMPC), cefaclor (CCL) and fosfomycin (FOM). MIC90 of these drugs were 3.13 μg/ml with NFLX, 0.39 μg/ml with MINO, >100 μg/ml with EM, 50 μg/ml with AMPC, >100 μg/ml with CCL and >100 μg/ml with FOM. MIC distribution patterns with 2 peaks were recognized with EM and FOM. Of 55 strains resistant to all of EM, AMPC, CCL and FOM, 50 and 54 strains were well susceptible to NFLX and MINO, respectively. The present investigation demonstrated relatively potent antibiotic effect of NFLX against MRSA. Considering the safety of NFLX to children which have been confirmed and reported separately, it can be concluded that NFLX is a useful oral antimicrobial drug in the treatment of children with MRSA infections.
UR - http://www.scopus.com/inward/record.url?scp=0025299038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025299038&partnerID=8YFLogxK
U2 - 10.11553/antibiotics1968b.43.228
DO - 10.11553/antibiotics1968b.43.228
M3 - Article
C2 - 2362350
AN - SCOPUS:0025299038
SN - 0368-2781
VL - 43
SP - 228
EP - 232
JO - the japanese journal of antibiotics
JF - the japanese journal of antibiotics
IS - 2
ER -
