Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Toru Yagura, Tomoko Motomiya, Michiho Ito, Gisho Honda, Akira Iida, Fumiyuki Kiuchi, Harukuni Tokuda, Hoyoku Nishino

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalJournal of Natural Medicines
Issue number2
Publication statusPublished - 2008 Apr
Externally publishedYes


  • Anticarcinogenic activity
  • Helichrysum maracandicum
  • Isosalipurposide
  • Naringenin chalcone
  • Two-stage carcinogenesis

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine
  • Pharmaceutical Science
  • Organic Chemistry


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