Anticoagulant factor protein S inhibits the proliferation of rat astrocytes after injury

Yoko I. Tomobe, Hiroshi Hama, Takeshi Sakurai, Akira Fujimori, Yoichiro Abe, Katsutoshi Goto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The actions of protein S (PS) on the scratch injury-induced proliferation of rat astrocytes (AC) were studied. PS (10-300 nM) markedly inhibited [3H]thymidine incorporation into injured AC. The effect of 100 nM PS was comparable with that of transforming growth factor-β1 (TGF-β1; 20 ng/ml). The incorporation of bromodeoxyuridine, which is usually detectable in AC along the border of the wound, was undetectable in the presence of 300 nM PS. The level of PS mRNA in the injured AC was slightly increased 15 h after the injury, although the level of its receptor, Tyro 3 mRNA was not changed significantly. The results of the present study suggest that PS plays an important role in tissue repair processes in the central nervous system (CNS) by suppressing the proliferation of AC as in the case of TGF-β1.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 1996 Aug 16
Externally publishedYes


  • Astrocyte
  • Growth inhibition
  • Proliferation
  • Protein S
  • Transforming growth factor-
  • Tyro 3

ASJC Scopus subject areas

  • General Neuroscience


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