TY - JOUR
T1 - Antihistamine effects on prefrontal cortex activity during working memory process in preschool children
T2 - A near-infrared spectroscopy (NIRS) study
AU - Tsujii, Takeo
AU - Yamamoto, Eriko
AU - Ohira, Takayuki
AU - Takahashi, Takao
AU - Watanabe, Shigeru
N1 - Funding Information:
Our thanks go to the 15 preschool children who participated in the study, as well as to their parents. We also thank Masahito Kobayashi, MD (Department of Neurosurgery, Keio University), Kenjiro Kosaki, MD (Department of Pediatrics, Keio University), and Shozo Kojima, PhD (Department of Psychology, Keio University), for valuable contributions toward the design and execution of this study. Funding for the study was provided by the Japanese Public Health Research Foundation (JPHRF). The study was conducted at the Center for Integrated Research on the Mind (CIRM) and was supported by grants of the 21st Century COE program from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2010/5
Y1 - 2010/5
N2 - Histamine H1 receptor antagonists (antihistamines) are widely used for the treatment of allergic disorders in young children. This study examined the effects of antihistamine on prefrontal cortex activity in preschool children using near-infrared spectroscopy (NIRS), an emerging brain-imaging method suitable for psychological experiments, especially in young children. We examined the changes of oxygenated hemoglobin concentration in the prefrontal cortex while children performed a spatial working memory task, 3h after taking a first-generation antihistamine (ketotifen), second-generation antihistamine (epinastine), or placebo. Fifteen healthy preschool children (mean age, 5.5 years) participated. Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex in the working memory task, compared with epinastine and placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. This paper demonstrates for the first time differential sedation effects of first- and second-generation antihistamines on brain hemodynamic response in young children. Also discussed is the utility of the NIRS technique in neuropsychopharmacological studies of children.
AB - Histamine H1 receptor antagonists (antihistamines) are widely used for the treatment of allergic disorders in young children. This study examined the effects of antihistamine on prefrontal cortex activity in preschool children using near-infrared spectroscopy (NIRS), an emerging brain-imaging method suitable for psychological experiments, especially in young children. We examined the changes of oxygenated hemoglobin concentration in the prefrontal cortex while children performed a spatial working memory task, 3h after taking a first-generation antihistamine (ketotifen), second-generation antihistamine (epinastine), or placebo. Fifteen healthy preschool children (mean age, 5.5 years) participated. Ketotifen significantly impaired behavioral performance and cortical activation at the lateral prefrontal cortex in the working memory task, compared with epinastine and placebo. There were no sedative effects on neural response or behavioral performance after epinastine administration. This paper demonstrates for the first time differential sedation effects of first- and second-generation antihistamines on brain hemodynamic response in young children. Also discussed is the utility of the NIRS technique in neuropsychopharmacological studies of children.
KW - Antihistamine
KW - Epinastine
KW - Histamine
KW - Ketotifen
KW - Near-infrared spectroscopy (NIRS)
KW - Preschool children
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=77952885363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952885363&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2010.01.010
DO - 10.1016/j.neures.2010.01.010
M3 - Article
C2 - 20138095
AN - SCOPUS:77952885363
SN - 0168-0102
VL - 67
SP - 80
EP - 85
JO - Neuroscience Research
JF - Neuroscience Research
IS - 1
ER -