Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Hong Jie Zhang; Pamela A. Tamez; Zeynep Aydogmus; Ghee Teng Tan; Yoko Saikawa; Kimiko Hashimoto; Masaya Nakata; Nguyen Van Hung; Le Thi Xuan; Nguyen Manh Cuong; D. Doel Soejarto; John M. Pezzuto; Harry H.S. Fong

doi:10.1055/s-2002-36350

Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Hong Jie Zhang, Pamela A. Tamez, Zeynep Aydogmus, Ghee Teng Tan, Yoko Saikawa, Kimiko Hashimoto, Masaya Nakata, Nguyen Van Hung, Le Thi Xuan, Nguyen Manh Cuong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC₅₀ values below 1 ng/ml.

Original language	English
Pages (from-to)	1088-1091
Number of pages	4
Journal	Planta Medica
Volume	68
Issue number	12
DOIs	https://doi.org/10.1055/s-2002-36350
Publication status	Published - 2002 Dec 1

Keywords

Antimalarial activity
Araceae
Bioassay-directed fractionation
Ficus fistulosa
Moraceae
Rhaphidophora decursiva
Roridin E
Trichothecene sesquiterpenoids
Verrucarin L acetate

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1055/s-2002-36350

Cite this

@article{e69bc6aae4ca4c549841e45e278d2108,

title = "Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva",

abstract = "Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.",

keywords = "Antimalarial activity, Araceae, Bioassay-directed fractionation, Ficus fistulosa, Moraceae, Rhaphidophora decursiva, Roridin E, Trichothecene sesquiterpenoids, Verrucarin L acetate",

author = "Zhang, {Hong Jie} and Tamez, {Pamela A.} and Zeynep Aydogmus and Tan, {Ghee Teng} and Yoko Saikawa and Kimiko Hashimoto and Masaya Nakata and Hung, {Nguyen Van} and Xuan, {Le Thi} and Cuong, {Nguyen Manh} and Soejarto, {D. Doel} and Pezzuto, {John M.} and Fong, {Harry H.S.}",

year = "2002",

month = dec,

day = "1",

doi = "10.1055/s-2002-36350",

language = "English",

volume = "68",

pages = "1088--1091",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "12",

}

TY - JOUR

T1 - Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

AU - Zhang, Hong Jie

AU - Tamez, Pamela A.

AU - Aydogmus, Zeynep

AU - Tan, Ghee Teng

AU - Saikawa, Yoko

AU - Hashimoto, Kimiko

AU - Nakata, Masaya

AU - Hung, Nguyen Van

AU - Xuan, Le Thi

AU - Cuong, Nguyen Manh

AU - Soejarto, D. Doel

AU - Pezzuto, John M.

AU - Fong, Harry H.S.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.

AB - Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.

KW - Antimalarial activity

KW - Araceae

KW - Bioassay-directed fractionation

KW - Ficus fistulosa

KW - Moraceae

KW - Rhaphidophora decursiva

KW - Roridin E

KW - Trichothecene sesquiterpenoids

KW - Verrucarin L acetate

UR - http://www.scopus.com/inward/record.url?scp=0036969333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036969333&partnerID=8YFLogxK

U2 - 10.1055/s-2002-36350

DO - 10.1055/s-2002-36350

M3 - Article

C2 - 12494335

AN - SCOPUS:0036969333

SN - 0032-0943

VL - 68

SP - 1088

EP - 1091

JO - Planta Medica

JF - Planta Medica

IS - 12

ER -

Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this