Antimetastatic effect by vaccination of tumor cells transfected with B7- 1 (CD80) gene

Y. Ohnishi, H. Fujii, M. Inobe, F. Kimura, J. Murata, M. Murakami, T. Uede, T. Sakamoto, K. Tazawa, M. Fujimaki, I. Saiki

Research output: Contribution to journalArticlepeer-review


In order to induce the efficient activation of T cells followed by anti- tumor immunity, we established B7+ tumor cells by transfection with B7-1 (CD80) gene into B16 BL6 melanoma cells (B7- cells) and investigated the effect of immunization with irradiated B7-transfected cells on experimental and spontaneous lung metastasis. Immunization of irradiated B7+ cells resulted in the remarkable reduction of lung tumor colonies as compared with B7- parental cells. Combination of vaccination with Lentinan/IL-2 led to the augmentation of anti metastatic effect.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
Issue number5
Publication statusPublished - 1997
Externally publishedYes


  • B7
  • IL-2
  • Lentinan
  • Metastasis
  • Vaccination

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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