TY - JOUR
T1 - Antioxidant activity and xanthine oxidase inhibition activity of reductic acid
T2 - Ascorbic acid analogue
AU - Mashino, Tadahiko
AU - Takigawa, Yasushi
AU - Saito, Naomi
AU - Wong, Liquing Q.
AU - Mochizuki, Masataka
N1 - Funding Information:
This work was supported in part by a grant from the Science Research Promotion and by a grant from the Science Research Promotion Fund of the Japan Private School Promotion Foundation.
PY - 2000/12/18
Y1 - 2000/12/18
N2 - Reductic acid (2,3-dihydroxy-2-cyclopentenone, 1) decreased the ESR signal of 5,5-dimethyl-1-pyrroline 1-oxide (DMPO)-OH produced by hydroxyl radical and DMPO. 1 also inhibited lipid peroxidation initiated by cytochrome P450 and tertbutyl hydroperoxide. 1 inhibited xanthine oxidase activity, while ascorbic acid and 2-hydroxytetronic acid, an ascorbic acid analogue without side chain, did not. (C) 2000 Elsevier Science Ltd.
AB - Reductic acid (2,3-dihydroxy-2-cyclopentenone, 1) decreased the ESR signal of 5,5-dimethyl-1-pyrroline 1-oxide (DMPO)-OH produced by hydroxyl radical and DMPO. 1 also inhibited lipid peroxidation initiated by cytochrome P450 and tertbutyl hydroperoxide. 1 inhibited xanthine oxidase activity, while ascorbic acid and 2-hydroxytetronic acid, an ascorbic acid analogue without side chain, did not. (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0960-894X(00)00570-9
DO - 10.1016/S0960-894X(00)00570-9
M3 - Article
C2 - 11133091
AN - SCOPUS:0034684751
SN - 0960-894X
VL - 10
SP - 2783
EP - 2785
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 24
ER -