Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells

Somchai Kritsanawong, Sukanda Innajak, Masaya Imoto, Ramida Watanapokasin

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63 Citations (Scopus)


α-Mangostin extracted from mangosteen, Garcinia mangostana Linn. is known as 'queen of fruits'. The anticancer activity of α-mangostin through apoptosis induction and related signaling pathways in human breast cancer T47D cells was investigated. Human epidermal growth factor receptor 2 (HER2) and mitogen-activated protein kinase (MAPK) signaling have been shown to play important roles in apoptosis. The results showed that α-mangostin induced cell proliferation inhibition, DNA fragmentation, nuclear condensation, increased cleaved caspase-3 and cleaved caspase-9, but decreased Bcl-2 and Mcl-1 expression. Mitochondrial dysfunction and cytochrome c release were also detected. In addition, phosphorylation of ERα, HER2, PI3K, Akt and ERK1/2 were downregulated whereas p-JNK1/2 and p-p38 were upregulated. These results indicated that α-mangostin induced apoptosis associated with HER2/PI3K/Akt and MAPK signaling pathways suggesting that α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.

Original languageEnglish
Pages (from-to)2155-2165
Number of pages11
JournalInternational journal of oncology
Issue number5
Publication statusPublished - 2016 May


  • Akt
  • Apoptosis
  • Breast cancer
  • MAPK
  • PI3K
  • α-mangostin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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