Antitumor effect of chemically synthesized (+)-goniopypyrone

T. K.M. Shing; M. Look; Y. M. Choy

doi:10.1159/000239115

Antitumor effect of chemically synthesized (+)-goniopypyrone

T. K.M. Shing, M. Look, Y. M. Choy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED₅₀ values were found to be 35 and 30 μg/ml for the two cell lines used. An LD₅₀ of 193 μg/ml was observed in the brine shrimp bioassay.

Original language	English
Pages (from-to)	132-134
Number of pages	3
Journal	CHEMOTHERAPY
Volume	39
Issue number	2
DOIs	https://doi.org/10.1159/000239115
Publication status	Published - 1993
Externally published	Yes

Keywords

(+)-epi-goniotriol
(+)-goniopypyrone
Ehrlich ascites tumor
PU5-1.8

ASJC Scopus subject areas

Oncology
Pharmacology
Drug Discovery
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000239115

Cite this

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title = "Antitumor effect of chemically synthesized (+)-goniopypyrone",

abstract = "Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 μg/ml for the two cell lines used. An LD50 of 193 μg/ml was observed in the brine shrimp bioassay.",

keywords = "(+)-epi-goniotriol, (+)-goniopypyrone, Ehrlich ascites tumor, PU5-1.8",

author = "Shing, {T. K.M.} and M. Look and Choy, {Y. M.}",

year = "1993",

doi = "10.1159/000239115",

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T1 - Antitumor effect of chemically synthesized (+)-goniopypyrone

AU - Shing, T. K.M.

AU - Look, M.

AU - Choy, Y. M.

PY - 1993

Y1 - 1993

N2 - Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 μg/ml for the two cell lines used. An LD50 of 193 μg/ml was observed in the brine shrimp bioassay.

AB - Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 μg/ml for the two cell lines used. An LD50 of 193 μg/ml was observed in the brine shrimp bioassay.

KW - (+)-epi-goniotriol

KW - (+)-goniopypyrone

KW - Ehrlich ascites tumor

KW - PU5-1.8

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UR - http://www.scopus.com/inward/citedby.url?scp=0027502468&partnerID=8YFLogxK

U2 - 10.1159/000239115

DO - 10.1159/000239115

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AN - SCOPUS:0027502468

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JF - CHEMOTHERAPY

IS - 2

ER -

Antitumor effect of chemically synthesized (+)-goniopypyrone

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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