@article{ea3eea657d394da0b35187905bfacc92,
title = "Aplyronines D-H from the sea hare Aplysia kurodai: Isolation, structures, and cytotoxicity",
abstract = "Five cytotoxic macrolides, aplyronines D-H (4-8), were isolated from the Japanese sea hare Aplysia kurodai. They are new congeners of the antitumor compound aplyronine A (1), which was previously isolated from the same organism. Their structures were determined by spectroscopic analysis (NMR and MS). The cytotoxicity of these new compounds was evaluated in comparison with that of aplyronines A-C (1-3), suggesting the importance of the 7-O-seryl ester group for mediating the potent cytotoxicity of aplyronines.",
keywords = "Aplyronine, Cytotoxicity, Isolation, Marine natural product, Sea hare, Structure",
author = "Makoto Ojika and Hideo Kigoshi and Kiyotake Suenaga and Yoshifumi Imamura and Kohji Yoshikawa and Takeshi Ishigaki and Akira Sakakura and Tsuyoshi Mutou and Kiyoyuki Yamada",
note = "Funding Information: We are grateful to Drs. Tomohisa Takita, Hisao Ekimoto, and Masayuki Arakawa, Nippon Kayaku Co. Ltd. for the evaluation of cytotoxicity and helpful discussions. This work was supported in part by a Grant-in-Aid for Scientific Research (nos. 04403009 and 03640472 ) from the Ministry of Education, Culture, Sports, Science, and Technology (Japan) , Fujisawa Foundation , Shorai Foundation for Science and Technology , Naito Foundation , Ciba-Geigy Foundation (Japan) for the Promotion of Science , Asahi Glass Foundation , and Ono Pharmaceutical Co . A Research Fellowship for Young Scientists to T.I. from the Japan Society for the Promotion of Science is gratefully acknowledged.",
year = "2012",
month = jan,
day = "28",
doi = "10.1016/j.tet.2011.11.095",
language = "English",
volume = "68",
pages = "982--987",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "4",
}