Applicability of second-generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study

Naoki Hosoe, Katsuyoshi Matsuoka, Makoto Naganuma, Yosuke Ida, Yuka Ishibashi, Kayoko Kimura, Kazuaki Yoneno, Shingo Usui, Kazuhiro Kashiwagi, Tadakazu Hisamatsu, Nagamu Inoue, Takanori Kanai, Hiroyuki Imaeda, Haruhiko Ogata, Toshifumi Hibi

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57 Citations (Scopus)


Background and Aim: Colon capsule endoscopy has already been used for colon visualization and detection of polyps but its applicability to inflammatory bowel disease is still unconfirmed. The aim of this study was to assess the feasibility of evaluating the severity of mucosal inflammation in patients with ulcerative colitis (UC) using a second-generation colon capsule endoscope (CCE-2). Methods: Forty patients with histological confirmed diagnosis of UC were enrolled. Low-volume (2L) polyethylene glycol solution with prokinetics (mosapride citrate and metoclopramide) regimen was used for the bowel preparation. In Phase 1, consisting of 10 patients, to confirm appropriate CCE-2 bowel preparation for UC. In Phase 2, consisting of 30 patients, CCE-2 was performed with a fixed bowel preparation regimen. CCE-2 findings were recorded for 8h starting from capsule ingestion and conventional colonoscopy was subsequently performed on the same day. CCE-2 procedure completion rate and the colon cleansing level with a 4-point grading scale (poor, fair, good, and excellent) were evaluated in Phase 2. Correlations between Matts endoscopic scores as judged by CCE-2 and conventional colonoscopy were calculated. Results: CCE-2 procedure was completed within 8h in 69% of the patients. The proportion of patients with good or excellent cleansing level was below 50%. However, Matts endoscopic scores determined by CCE-2 showed a strong correlation with scores obtained by conventional colonoscopy (average ρ=0.797). Conclusions: Although modifications in bowel preparation are needed, CCE-2 might be feasible for assessing the severity of mucosal inflammation in patients with UC.

Original languageEnglish
Pages (from-to)1174-1179
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number7
Publication statusPublished - 2013 Jul


  • Colon capsule endoscopy
  • Colonoscopy
  • Polyethylene glycol
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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