Application of Liquid Particle extraction to the Purification of Glycyrrhizin

Hideyuki Nishizawa, Sakiko Okimura, Yukako Watanabe, Yoshihiro Abe

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Glycyrrhizin on the market (about 90% in purity) contains two major impurities which are difficult to remove by recrystallization. Purification of a commercial sample was carried out by a dual-flow countercurrent extraction method, liquid particle extraction, which was recently introduced. Starting from 72.6 mg of commercial glycyrrhizin, it was purified to a purity of 99.7% with a recovery of 53.9% (35.3 me).

Original languageEnglish
Pages (from-to)969-971
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number4
Publication statusPublished - 1991
Externally publishedYes


  • extraction
  • glycyrrhizic acid
  • glycyrrhizin
  • liquid particle extraction
  • purification

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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