TY - JOUR
T1 - Application of Photoacoustic Imaging for Lymphedema Treatment
AU - Suzuki, Yushi
AU - Kajita, Hiroki
AU - Watanabe, Shiho
AU - Okabe, Keisuke
AU - Sakuma, Hisashi
AU - Imanishi, Nobuaki
AU - Aiso, Sadakazu
AU - Kishi, Kazuo
N1 - Funding Information:
PAI-05 that we used in this manuscript was provided free of charge from Luxonus Inc. to Keio University School of Medicine. Dr. Aiso is CEO of the Luxonus Inc. Dr. Suzuki reports grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), grants from Grant from AMED, during the conduct of the study. Dr. Kajita reports grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), grants from Tobikai Medical Corporation, grants from Japan Agency for Medical Research and Development (AMED), non-financial support from Luxonus, Inc, during the conduct of the study. In addition, Dr. Kajita has a patent PCT/JP2019/032560 pending, a patent PCT/JP2019/032564 pending, a patent PCT/ JP2019/032586 pending, a patent PCT/JP2019/013968 pending, a patent PCT/JP2019/013953 pending, a patent PCT/JP2019/013940 pending, a patent JP2018–157800 pending, a patent U.S. Patent Application No. 16/542,681 pending, a patent JP2018–157798 pending, a patent JP2018–157797 pending, a patent JP2018–157794 pending, a patent JP2018–157785 pending, a patent JP2018–157755 pending, a patent JP2018–157752 pending, a patent JP2018–155043 pending, a patent JP2018–155034 pending, and a patent JP2018–155033 pending. Dr. Imanishi reports grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), grants from Tobikai Medical Corporation, grants from Japan Agency for Medical Research and Development (AMED), non-financial support from Luxonus, Inc, during the conduct of the study. In addition, Dr. Imanishi has a patent PCT/JP2019/032560 pending, a patent PCT/JP2019/ 032564 pending, a patent PCT/JP2019/032586 pending, a patent PCT/JP2019/013968 pending, a patent PCT/JP2019/ 013953 pending, a patent PCT/JP2019/013940 pending, a patent JP2018–157800 pending, a patent U.S. Patent Application No. 16/542,681 pending, a patent JP2018–157798 pending, a patent JP2018–157797 pending, a patent JP2018–157794 pending, a patent JP2018–157785 pending, a patent JP2018–157755 pending, a patent JP2018–157752 pending, a patent JP2018–155043 pending, a patent JP2018–155034 pending, and a patent JP2018–155033 pending. Dr. Sakuma reports grants from Japan Agency for Medical Research and Development (AMED), grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), nonfinancial support from Luxonus, Inc, non-financial support from Canon, Inc, outside the submitted work. Dr. Kishi reports grants from Japan Agency for Medical Research and Development (AMED), grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), non-financial support from Luxonus, Inc, non-financial support from Canon, Inc, during the conduct of the study. Dr. Okabe reports grants from Japan Agency for Medical Research and Development (AMED), grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), non-financial support from Luxonus, Inc, non-financial support from Canon, Inc, during the conduct of the study. Dr. Aiso reports grants from Japan Agency for Medical Research and Development (AMED), grants from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), CEO and shareholder of Luxonus, Inc, non-financial support from Canon, Inc, during the conduct of the study; personal fees and other from Luxonus, Inc., outside the submitted work; and is getting personal fee from the company, as well as is a shareholder of the company.
Funding Information:
This research was funded by a grant from ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office,GovernmentofJapan)andtheJapanAgencyforMedical Research and Development (AMED) JP21he2302002.
Publisher Copyright:
© 2022 Georg Thieme Verlag. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Background Lymphatic vessels are difficult to identify using existing modalities as because of their small diameter and the transparency of the lymph fluid flowing through them. Methods Here, we introduce photoacoustic lymphangiography (PAL), a new modality widely used for lymphedema treatment, to observe limb lymphatic vessels. The photoacoustic imaging system used in this study can simultaneously visualize lymphatic vessels and veins with a high resolution (0.2 mm) and can also observe their three-dimensional relationship with each other. Results High-resolution images of the lymphatic vessels, detailed structure of the dermal back flow, and the three-dimensional positional relationship between the lymphatic vessels and veins were observed by PAL. Conclusion The clear image provided by PAL could have a major application in pre- and postoperative use during lymphaticovenular anastomosis for lymphedema treatment.
AB - Background Lymphatic vessels are difficult to identify using existing modalities as because of their small diameter and the transparency of the lymph fluid flowing through them. Methods Here, we introduce photoacoustic lymphangiography (PAL), a new modality widely used for lymphedema treatment, to observe limb lymphatic vessels. The photoacoustic imaging system used in this study can simultaneously visualize lymphatic vessels and veins with a high resolution (0.2 mm) and can also observe their three-dimensional relationship with each other. Results High-resolution images of the lymphatic vessels, detailed structure of the dermal back flow, and the three-dimensional positional relationship between the lymphatic vessels and veins were observed by PAL. Conclusion The clear image provided by PAL could have a major application in pre- and postoperative use during lymphaticovenular anastomosis for lymphedema treatment.
KW - lymphatic vessels
KW - lymphaticovenular anastomosis
KW - lymphedema
KW - photoacoustic lymphangiography
UR - http://www.scopus.com/inward/record.url?scp=85122531952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122531952&partnerID=8YFLogxK
U2 - 10.1055/s-0041-1736518
DO - 10.1055/s-0041-1736518
M3 - Review article
C2 - 34959248
AN - SCOPUS:85122531952
SN - 0743-684X
VL - 38
SP - 254
EP - 262
JO - Journal of Reconstructive Microsurgery
JF - Journal of Reconstructive Microsurgery
IS - 3
ER -