Aquaporins and disease: Lessons from mice to humans

Landon S. King, Masato Yasui

Research output: Contribution to journalReview articlepeer-review

74 Citations (Scopus)


Recent discovery of a family of water-specific membrane channel proteins, the aquaporins, has provided new insights into the molecular basis of membrane water permeability. Eleven mammalian aquaporins have been identified to date, with homolog present across the spectrum of life, including bacteria, yeast and plants. The distribution of the mammalian aquaporins predicts their participation in a range of pathophysiological events. Empirical evidence of a physiological role for aquaporins is emerging from studies in both mice and humans, and suggests that aquaporins are likely to play significant roles in human pathophysiology.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number8
Publication statusPublished - 2002 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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