Assessment of Bioabsorbable Hydroxyapatite for Secondary Bone Grafting in Unilateral Alveolar Clefts

Yoshiaki Sakamoto, Teruo Sakamoto, Tekenobu Ishii, Kazuo Kishi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Purpose: To evaluate the utility and efficacy of bioabsorbable hydroxyapatite and collagen complex (HA/Col) for secondary bone grafting in unilateral alveolar clefts. Patients and Methods: Between 2015 and 2016, 21 patients with unilateral cleft lips and alveolar clefts were enrolled. In group I, a cancellous iliac bone graft was placed at the alveolar cleft (6 males, 5 females). In group II, a bioabsorbable HA/Col was placed at the alveolar cleft (4 males, 7 females). Results: The groups did not differ in age, cleft volume, or surgical duration. There was a significant difference in intraoperative blood loss between the 2 groups (6.7 ± 1.89 mL in group II vs 38.8 ± 9.73 mL in group I [P <.01]). The use of patient-controlled intravenous analgesia was also significantly lower in group II than in group I (2.2 ± 1.9 times vs 12.2 ± 4.4 times [P <.01]). Only 1 female in group II who had maxillary sinusitis did not achieve osteosynthesis. With the exception of this patient, the 12-month bone volumes in groups I and II were 0.567 ± 0.066 and 0.596 ± 0.073 mL, respectively, without significant difference (P =.18). Conclusion: Compared with an autogenous bone, bioabsorbable HA/Col significantly reduces postoperative pain. In addition, the use of HA/Col alone produced the same result as an autologous bone and is effective in filling the alveolar cleft.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalCleft Palate-Craniofacial Journal
Issue number1
Publication statusPublished - 2020 Jan 1


  • bone grafting
  • bone regeneration
  • computerized tomography
  • maxilla

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology


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