Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury

Zijian Lou; Alex Post; Narihito Nagoshi; James Hong; Nader Hejrati; Jonathon Chon Teng Chio; Mohamad Khazaei; Michael G. Fehlings

doi:10.1093/stcltm/szae090

Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury

Zijian Lou
, Alex Post
, Narihito Nagoshi
, James Hong
, Nader Hejrati
, Jonathon Chon Teng Chio
, Mohamad Khazaei
, Michael G. Fehlings

Department of Orthopaedics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.

Original language	English
Article number	szae090
Journal	Stem Cells Translational Medicine
Volume	14
Issue number	2
DOIs	https://doi.org/10.1093/stcltm/szae090
Publication status	Published - 2025 Feb 1

Keywords

gene expression
immunosuppression
neural progenitor cells
spinal cord injury
transplantation

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1093/stcltm/szae090

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title = "Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury",

abstract = "Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.",

keywords = "gene expression, immunosuppression, neural progenitor cells, spinal cord injury, transplantation",

author = "Zijian Lou and Alex Post and Narihito Nagoshi and James Hong and Nader Hejrati and Chio, \{Jonathon Chon Teng\} and Mohamad Khazaei and Fehlings, \{Michael G.\}",

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AU - Lou, Zijian

AU - Post, Alex

AU - Nagoshi, Narihito

AU - Hong, James

AU - Hejrati, Nader

AU - Chio, Jonathon Chon Teng

AU - Khazaei, Mohamad

AU - Fehlings, Michael G.

N1 - Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press.

PY - 2025/2/1

Y1 - 2025/2/1

N2 - Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.

AB - Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.

KW - gene expression

KW - immunosuppression

KW - neural progenitor cells

KW - spinal cord injury

KW - transplantation

UR - https://www.scopus.com/pages/publications/85217794831

UR - https://www.scopus.com/pages/publications/85217794831#tab=citedBy

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JO - Stem Cells Translational Medicine

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Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury

Abstract

Keywords

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