Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

Toshio Kojima; Hidehiko Kamei; Tomoyuki Aizu; Yasumichi Arai; Michiyo Takayama; Susumu Nakazawa; Yoshinori Ebihara; Hiroki Inagaki; Yukie Masui; Yasuyuki Gondo; Yoshiyuki Sakaki; Nobuyoshi Hirose

doi:10.1016/j.exger.2004.05.007

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

Toshio Kojima, Hidehiko Kamei, Tomoyuki Aizu, Yasumichi Arai, Michiyo Takayama, Susumu Nakazawa, Yoshinori Ebihara, Hiroki Inagaki, Yukie Masui, Yasuyuki Gondo, Yoshiyuki Sakaki, Nobuyoshi Hirose

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were FOXO1A, INSR, IRS1, PIK3CB, PIK3CG, and PPARGC1A. We investigated the possible association of each gene locus and longevity by haplotype-based association analyses using 18 SNPs from public databases and the published literature. One INSR haplotype, which was comprised of 2 SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls.

Original language	English
Pages (from-to)	1595-1598
Number of pages	4
Journal	Experimental Gerontology
Volume	39
Issue number	11-12 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.exger.2004.05.007
Publication status	Published - 2004 Nov

Keywords

Aging
Centenarian
Gene polymorphism
Insulin/IGF1 signaling
Longevity

ASJC Scopus subject areas

Biochemistry
Ageing
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2004.05.007

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Kojima, T., Kamei, H., Aizu, T., Arai, Y., Takayama, M., Nakazawa, S., Ebihara, Y., Inagaki, H., Masui, Y., Gondo, Y., Sakaki, Y., & Hirose, N. (2004). Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Experimental Gerontology, 39(11-12 SPEC. ISS.), 1595-1598. https://doi.org/10.1016/j.exger.2004.05.007

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. / Kojima, Toshio; Kamei, Hidehiko; Aizu, Tomoyuki et al.
In: Experimental Gerontology, Vol. 39, No. 11-12 SPEC. ISS., 11.2004, p. 1595-1598.

Research output: Contribution to journal › Article › peer-review

Kojima, T, Kamei, H, Aizu, T, Arai, Y , Takayama, M, Nakazawa, S, Ebihara, Y, Inagaki, H, Masui, Y, Gondo, Y, Sakaki, Y & Hirose, N 2004, 'Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways', Experimental Gerontology, vol. 39, no. 11-12 SPEC. ISS., pp. 1595-1598. https://doi.org/10.1016/j.exger.2004.05.007

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title = "Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways",

abstract = "Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were FOXO1A, INSR, IRS1, PIK3CB, PIK3CG, and PPARGC1A. We investigated the possible association of each gene locus and longevity by haplotype-based association analyses using 18 SNPs from public databases and the published literature. One INSR haplotype, which was comprised of 2 SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls.",

keywords = "Aging, Centenarian, Gene polymorphism, Insulin/IGF1 signaling, Longevity",

author = "Toshio Kojima and Hidehiko Kamei and Tomoyuki Aizu and Yasumichi Arai and Michiyo Takayama and Susumu Nakazawa and Yoshinori Ebihara and Hiroki Inagaki and Yukie Masui and Yasuyuki Gondo and Yoshiyuki Sakaki and Nobuyoshi Hirose",

note = "Funding Information: We greatly appreciate involvement of the SSCs in this study and their family members for their time and assistance. This study could not have been performed without their kind cooperation. We thank Wakako Hashimoto, Fumiwo Ejima, Aki Nishida, Yan Li, and other members of RIKEN HGRG for their contributions to this study. This work was supported in part by a grant to RIKEN GSC from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

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AU - Kamei, Hidehiko

AU - Aizu, Tomoyuki

AU - Arai, Yasumichi

AU - Takayama, Michiyo

AU - Nakazawa, Susumu

AU - Ebihara, Yoshinori

AU - Inagaki, Hiroki

AU - Masui, Yukie

AU - Gondo, Yasuyuki

AU - Sakaki, Yoshiyuki

AU - Hirose, Nobuyoshi

N1 - Funding Information: We greatly appreciate involvement of the SSCs in this study and their family members for their time and assistance. This study could not have been performed without their kind cooperation. We thank Wakako Hashimoto, Fumiwo Ejima, Aki Nishida, Yan Li, and other members of RIKEN HGRG for their contributions to this study. This work was supported in part by a grant to RIKEN GSC from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2004/11

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N2 - Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were FOXO1A, INSR, IRS1, PIK3CB, PIK3CG, and PPARGC1A. We investigated the possible association of each gene locus and longevity by haplotype-based association analyses using 18 SNPs from public databases and the published literature. One INSR haplotype, which was comprised of 2 SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls.

AB - Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were FOXO1A, INSR, IRS1, PIK3CB, PIK3CG, and PPARGC1A. We investigated the possible association of each gene locus and longevity by haplotype-based association analyses using 18 SNPs from public databases and the published literature. One INSR haplotype, which was comprised of 2 SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls.

KW - Aging

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Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

Abstract

Keywords

ASJC Scopus subject areas

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