TY - JOUR
T1 - Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm
AU - Fukushima, Genki
AU - Abe, Kodai
AU - Kitago, Minoru
AU - Iwasaki, Eisuke
AU - Hirata, Aya
AU - Takemura, Ryo
AU - Ishii, Ryota
AU - Yagi, Hiroshi
AU - Abe, Yuta
AU - Hasegawa, Yasushi
AU - Fukuhara, Seiichiro
AU - Hori, Shutaro
AU - Tanaka, Masayuki
AU - Nakano, Yutaka
AU - Yokose, Takahiro
AU - Shimane, Gaku
AU - Kitagawa, Yuko
N1 - Funding Information:
This work was supported by Kenko Kagaku Zaidan (grant KenkoKagakuZaidan201902). The funder had no involvement in this study.
Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Objectives Some intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can become pancreatic cancer. The mechanism behind the malignant progression of IPMN remains unknown. We aimed to identify the risk factors and interactions between backgrounds for IPMN. Methods We retrospectively enrolled 980 patients of pancreatic cancer or suspected IPMN (sIPMN) who underwent endoscopic ultrasound or retrograde cholangiopancreatography. We classified them into pancreatic cancer, high-risk sIPMN, and low-risk sIPMN, and investigated the risk factors for high-risk sIPMN. Results Smoking habits (odds ratio [OR], 3.74; 95% confidence interval [CI], 2.04-6.85; P < 0.001), serum carbohydrate antigen 19-9 ≥37 U/mL (OR, 6.30; 95% CI, 2.88-13.80; P < 0.001), and family history of cancers (OR, 2.38; 95% CI, 1.30-4.37; P = 0.005) were independent risk factors for high-risk suspected IPMN. Odds ratios of diabetes and neutrophil-to-lymphocyte ratio of 2.45 or greater were significantly higher in patients with a family history of cancer than those without a family history of cancer (OR, 3.28; 95% CI, 0.52-20.80 vs 1.85; 95% CI, 0.78-4.41; OR, 2.44; 95% CI, 0.81-7.34 vs 1.24; 95% CI, 0.67-2.30, respectively). Conclusions Understanding the interactions between background factors can effectively prevent IPMNs' malignant transformation.
AB - Objectives Some intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can become pancreatic cancer. The mechanism behind the malignant progression of IPMN remains unknown. We aimed to identify the risk factors and interactions between backgrounds for IPMN. Methods We retrospectively enrolled 980 patients of pancreatic cancer or suspected IPMN (sIPMN) who underwent endoscopic ultrasound or retrograde cholangiopancreatography. We classified them into pancreatic cancer, high-risk sIPMN, and low-risk sIPMN, and investigated the risk factors for high-risk sIPMN. Results Smoking habits (odds ratio [OR], 3.74; 95% confidence interval [CI], 2.04-6.85; P < 0.001), serum carbohydrate antigen 19-9 ≥37 U/mL (OR, 6.30; 95% CI, 2.88-13.80; P < 0.001), and family history of cancers (OR, 2.38; 95% CI, 1.30-4.37; P = 0.005) were independent risk factors for high-risk suspected IPMN. Odds ratios of diabetes and neutrophil-to-lymphocyte ratio of 2.45 or greater were significantly higher in patients with a family history of cancer than those without a family history of cancer (OR, 3.28; 95% CI, 0.52-20.80 vs 1.85; 95% CI, 0.78-4.41; OR, 2.44; 95% CI, 0.81-7.34 vs 1.24; 95% CI, 0.67-2.30, respectively). Conclusions Understanding the interactions between background factors can effectively prevent IPMNs' malignant transformation.
KW - family history
KW - malignancy
KW - neutrophil-to-lymphocyte ratio
KW - pancreatic neoplasms
KW - risk factors
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U2 - 10.1097/MPA.0000000000002064
DO - 10.1097/MPA.0000000000002064
M3 - Article
C2 - 36099509
AN - SCOPUS:85139571232
SN - 0885-3177
VL - 51
SP - 617
EP - 623
JO - Pancreas
JF - Pancreas
IS - 6
ER -
