Association Between Fatty Acid Intakes and Age-Related Macular Degeneration in a Japanese Population: JPHC-NEXT Eye Study

Tomoyo Yasukawa, Mariko Sasaki, Kaoru Motomura, Kenya Yuki, Toshihide Kurihara, Yohei Tomita, Kiwako Mori, Nobuhiro Ozawa, Yoko Ozawa, Kazumasa Yamagishi, Akiko Hanyuda, Norie Sawada, Kazuo Tsubota, Shoichiro Tsugane, Hiroyasu Iso

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Purpose: To determine the associations between fatty acid intakes and the prevalence of age-related macular degeneration (AMD) under a population-based cross-sectional study. Methods: Residents of Chikusei City aged ≥40 years underwent systemic and eye screening. AMD was graded according to a modified version of the Age-Related Eye Disease Study classification. Dietary intake was assessed using a food frequency questionnaire and was adjusted for total energy intake. Results: Altogether, 10,788 eyes of 5394 participants, 2116 men (mean [standard devia-tion (SD)] age, 62.4 [9.4] years) and 3278 women (60.6 [9.5] years), were included. The mean daily total fat intakes were 52.8 g and 59.0 g in men and women, respectively. After adjustments for potential confounders, saturated fatty acid (SFA) intake was inversely associated with the prevalence of any AMD in men (for each energy-adjusted 1-SD increase: odds ratio [OR], 0.86; 95% confidence interval [CI], 0.74–1.00). Significant trends were found for decreasing odds ratios of AMD with increasing SFA, monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA) intake (P for trend = 0.02, 0.04, and 0.04, respectively). In women, only a significant association was observed between the second quartile of linolenic acid intake and the prevalence of any AMD (OR, 0.78; 95% CI, 0.62–0.99). Conclusions: We found an inverse association of SFA intake and a weak inverse association of MUFA and PUFA intakes with the prevalence of any AMD in a Japanese popula-tion. Translational Relevance: Adequate fatty acid intake may be necessary to prevent or decelerate AMD.

Original languageEnglish
Article number3
JournalTranslational Vision Science and Technology
Issue number1
Publication statusPublished - 2023 Jan 1


  • age-related macular degeneration
  • dietaryintake
  • epidemiology
  • fattyacids
  • retina

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology


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