TY - JOUR
T1 - Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population
T2 - The SONIC study
AU - Onishi, Yuri
AU - Akasaka, Hiroshi
AU - Hatta, Kodai
AU - Terashima, Ken
AU - Yoshida, Shino
AU - Yasunobe, Yukiko
AU - Fujimoto, Taku
AU - Isaka, Masaaki
AU - Godai, Kayo
AU - Kido, Michiko
AU - Kabayama, Mai
AU - Sugimoto, Ken
AU - Masui, Yukie
AU - Matsumoto, Kiyoaki
AU - Yasumoto, Saori
AU - Ogawa, Madoka
AU - Nakagawa, Takeshi
AU - Arai, Yasumichi
AU - Ishizaki, Tatsuro
AU - Gondo, Yasuyuki
AU - Ikebe, Kazunori
AU - Kamide, Kei
AU - Yamamoto, Koichi
N1 - Publisher Copyright:
© 2024 The Author(s). Geriatrics & Gerontology International published by John Wiley & Sons Australia, Ltd on behalf of Japan Geriatrics Society.
PY - 2024/9
Y1 - 2024/9
N2 - Aim: Vitamin D (VD) affects skeletal muscles. The high prevalence of VD deficiency in Japan may lead to decreased skeletal muscle mass and strength, increasing the prevalence of sarcopenia. Therefore, we aimed to investigate the association between serum VD levels and skeletal muscle indices in a Japanese community-dwelling older population. Methods: We extracted data from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study. We analyzed the data for participants in the 70s and 90s age groups. Skeletal mass index (SMI) using bioimpedance analysis, grip strength, walking speed, and serum VD levels using 25-hydroxyvitamin D [25(OH)D] were measured. Results: We analyzed the data of 310 participants in their 70s and 48 in their 90s. Mean serum 25(OH)D levels were 21.6 ± 5.0 ng/mL in the 70s group and 23.4 ± 9.1 ng/mL in the 90s group. In the 70s group, serum 25(OH)D levels correlated with SMI (r = 0.21, P < 0.0001) and grip strength (r = 0.30, P < 0.0001). Serum 25(OH)D levels were independently associated with SMI after adjusting for sex, body mass index, and serum albumin levels. In the 90s group, serum 25(OH)D levels were correlated with SMI (r = 0.29, P = 0.049) and grip strength (r = 0.34, P = 0.018). However, the multivariate analysis showed no independent association between SMI, grip strength, and serum 25(OH)D levels. Conclusion: In a cross-sectional analysis of an older population, serum VD levels were associated with SMI and grip strength, and this association was more pronounced in the 70s group than in the 90s group. Our results suggest that serum VD levels maintain skeletal muscle mass and grip strength. Geriatr Gerontol Int 2024; 24: 898–903.
AB - Aim: Vitamin D (VD) affects skeletal muscles. The high prevalence of VD deficiency in Japan may lead to decreased skeletal muscle mass and strength, increasing the prevalence of sarcopenia. Therefore, we aimed to investigate the association between serum VD levels and skeletal muscle indices in a Japanese community-dwelling older population. Methods: We extracted data from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study. We analyzed the data for participants in the 70s and 90s age groups. Skeletal mass index (SMI) using bioimpedance analysis, grip strength, walking speed, and serum VD levels using 25-hydroxyvitamin D [25(OH)D] were measured. Results: We analyzed the data of 310 participants in their 70s and 48 in their 90s. Mean serum 25(OH)D levels were 21.6 ± 5.0 ng/mL in the 70s group and 23.4 ± 9.1 ng/mL in the 90s group. In the 70s group, serum 25(OH)D levels correlated with SMI (r = 0.21, P < 0.0001) and grip strength (r = 0.30, P < 0.0001). Serum 25(OH)D levels were independently associated with SMI after adjusting for sex, body mass index, and serum albumin levels. In the 90s group, serum 25(OH)D levels were correlated with SMI (r = 0.29, P = 0.049) and grip strength (r = 0.34, P = 0.018). However, the multivariate analysis showed no independent association between SMI, grip strength, and serum 25(OH)D levels. Conclusion: In a cross-sectional analysis of an older population, serum VD levels were associated with SMI and grip strength, and this association was more pronounced in the 70s group than in the 90s group. Our results suggest that serum VD levels maintain skeletal muscle mass and grip strength. Geriatr Gerontol Int 2024; 24: 898–903.
KW - SONIC study
KW - grip strength
KW - skeletal muscle
KW - vitamin D
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U2 - 10.1111/ggi.14951
DO - 10.1111/ggi.14951
M3 - Article
C2 - 39091107
AN - SCOPUS:85200243412
SN - 1444-1586
VL - 24
SP - 898
EP - 903
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
IS - 9
ER -