TY - JOUR
T1 - Association between uric acid and atherosclerosis in community-dwelling older people
T2 - The SONIC study
AU - the SONIC study group
AU - Tanaka, Kentaro
AU - Kabayama, Mai
AU - Sugimoto, Ken
AU - Akasaka, Hiroshi
AU - Takami, Yoichi
AU - Takeya, Yasushi
AU - Yamamoto, Koichi
AU - Sekiguchi, Toshiaki
AU - Kiyoshige, Eri
AU - Akagi, Yuya
AU - Godai, Kayo
AU - Yasumoto, Saori
AU - Masui, Yukie
AU - Gondo, Yasuyuki
AU - Ikebe, Kazunori
AU - Arai, Yasumichi
AU - Ishizaki, Tatsuro
AU - Rakugi, Hiromi
AU - Kamide, Kei
N1 - Funding Information:
This work was supported by honoraria from Daiichi‐Sankyo Co. Ltd. (KK) and research funding from Omron Health Care. Co. Ltd. (KK, MK).
Funding Information:
We are grateful to all SONIC participants who too part in these studies. We appreciate all the staff involved in the SONIC study, particularly Yumiko Aoshima and Tae Matsue for their secretarial work and support. The members of the SONIC Study Group (in addition to the authors) are as follows: Kazuya Taira, Tomoko Noma, Werayuth Srithumsuk, Nonglak Klinpudtan, Yasuka Sawayama, Takako Inoue, Naoko Wada and Atsuko Higuchi at the Division of Health Sciences, Osaka University Graduate School of Medicine; Serina Yokoyama, Satomi Maeda, Motonori Nagasawa and Taku Fujimoto at the Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine; Professor Shinichi Sato at the Osaka University, Graduate School of Human Sciences; Yoshiko Ishioka at Keio University; Megumi Tabuchi at Chukyo University; and Kenichi Matsuda, Taiji Ogawa, Masahiro Kitamura and Yoshinobu Maeda at Osaka University Graduate School of Dentistry.
Publisher Copyright:
© 2020 Japan Geriatrics Society
PY - 2021/1
Y1 - 2021/1
N2 - Aim: The association between serum uric acid (UA) and atherosclerosis in old people is controversial. Therefore, in this study, we clarified this association by assessing serum UA and common carotid atherosclerosis examined by carotid ultrasound in community-dwelling older people in their 70s, 80s and 90s in the SONIC study. Methods: A cross-sectional study was conducted involving 538 men and 577 women recruited from the community. The analysis was performed using serum UA as the explanatory variable and the maximum carotid intima-media thickness (max-CIMT) and mean-IMT as the dependent variables. The analysis was performed by multiple regression using traditional risk factors for atherosclerosis as adjustment variables. Results: Analysis of the association between serum UA and IMT revealed a significant correlation only in women >70 years old. Max-CIMT (β = 0.081, 95% CI = 0.026, 0.136; P = 0.004) and mean-IMT (β = 0.015, 95% CI = 0.003, 0.029; P = 0.016) were significant. In the analysis of each age group, a significant correlation was only found in women in their 70s for mean-IMT (β = 0.031, 95% CI = 0.008, 0.053; P = 0.008). Conclusion: In community-dwelling women aged about 70 years old, elevated serum UA may be an independent risk factor for IMT thickening as a surrogate marker for atherosclerosis. Geriatr Gerontol Int 2021; 21: 94–101.
AB - Aim: The association between serum uric acid (UA) and atherosclerosis in old people is controversial. Therefore, in this study, we clarified this association by assessing serum UA and common carotid atherosclerosis examined by carotid ultrasound in community-dwelling older people in their 70s, 80s and 90s in the SONIC study. Methods: A cross-sectional study was conducted involving 538 men and 577 women recruited from the community. The analysis was performed using serum UA as the explanatory variable and the maximum carotid intima-media thickness (max-CIMT) and mean-IMT as the dependent variables. The analysis was performed by multiple regression using traditional risk factors for atherosclerosis as adjustment variables. Results: Analysis of the association between serum UA and IMT revealed a significant correlation only in women >70 years old. Max-CIMT (β = 0.081, 95% CI = 0.026, 0.136; P = 0.004) and mean-IMT (β = 0.015, 95% CI = 0.003, 0.029; P = 0.016) were significant. In the analysis of each age group, a significant correlation was only found in women in their 70s for mean-IMT (β = 0.031, 95% CI = 0.008, 0.053; P = 0.008). Conclusion: In community-dwelling women aged about 70 years old, elevated serum UA may be an independent risk factor for IMT thickening as a surrogate marker for atherosclerosis. Geriatr Gerontol Int 2021; 21: 94–101.
KW - atherosclerosis
KW - carotid ultrasound
KW - community-dwelling older people
KW - gender difference
KW - uric acid
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U2 - 10.1111/ggi.14081
DO - 10.1111/ggi.14081
M3 - Article
C2 - 33166058
AN - SCOPUS:85100280641
SN - 1444-1586
VL - 21
SP - 94
EP - 101
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
IS - 1
ER -