TY - JOUR
T1 - Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions
AU - Takeuchi, Hikaru
AU - Taki, Yasuyuki
AU - Nouchi, Rui
AU - Yokoyama, Ryoichi
AU - Kotozaki, Yuka
AU - Nakagawa, Seishu
AU - Sekiguchi, Atsushi
AU - Iizuka, Kunio
AU - Yamamoto, Yuki
AU - Hanawa, Sugiko
AU - Araki, Tsuyoshi
AU - Miyauchi, Carlos Makoto
AU - Sakaki, Kohei
AU - Nozawa, Takayuki
AU - Ikeda, Shigeyuki
AU - Yokota, Susumu
AU - Daniele, Magistro
AU - Sassa, Yuko
AU - Kawashima, Ryuta
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Although copper plays a critical role in normal brain functions and development, it is known that excess copper causes toxicity. Here we investigated the associations of copper levels in the hair with regional gray matter volume (rGMV), mean diffusivity (MD), and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that high copper levels were associated mostly with low cognitive abilities (low scores on the intelligence test consisting of complex speed tasks, involving reasoning task, a complex arithmetic task, and a reading comprehension task) as well as lower reverse Stroop interference, high rGMV over widespread areas of the brain [mainly including the bilateral lateral and medial parietal cortices, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), middle cingulate cortex, orbitofrontal cortex, insula, perisylvian areas, inferior temporal lobe, temporal pole, occipital lobes, and supplementary motor area], as well as high MD of the right substantia nigra and bilateral hippocampus, which are indicative of low density in brain tissues. These results suggest that copper levels are associated with mostly aberrant cognitive functions, greater rGMV in extensive areas, greater MD (which are indicative of low density in brain tissues) in subcortical structures in the healthy young adults, possibly reflecting copper’s complex roles in neural mechanisms.
AB - Although copper plays a critical role in normal brain functions and development, it is known that excess copper causes toxicity. Here we investigated the associations of copper levels in the hair with regional gray matter volume (rGMV), mean diffusivity (MD), and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that high copper levels were associated mostly with low cognitive abilities (low scores on the intelligence test consisting of complex speed tasks, involving reasoning task, a complex arithmetic task, and a reading comprehension task) as well as lower reverse Stroop interference, high rGMV over widespread areas of the brain [mainly including the bilateral lateral and medial parietal cortices, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), middle cingulate cortex, orbitofrontal cortex, insula, perisylvian areas, inferior temporal lobe, temporal pole, occipital lobes, and supplementary motor area], as well as high MD of the right substantia nigra and bilateral hippocampus, which are indicative of low density in brain tissues. These results suggest that copper levels are associated with mostly aberrant cognitive functions, greater rGMV in extensive areas, greater MD (which are indicative of low density in brain tissues) in subcortical structures in the healthy young adults, possibly reflecting copper’s complex roles in neural mechanisms.
KW - Cognitive functions
KW - Copper
KW - Mean diffusivity
KW - Regional gray matter volume
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U2 - 10.1007/s00429-019-01830-y
DO - 10.1007/s00429-019-01830-y
M3 - Article
C2 - 30656448
AN - SCOPUS:85060225343
SN - 1863-2653
VL - 224
SP - 1203
EP - 1217
JO - Brain Structure and Function
JF - Brain Structure and Function
IS - 3
ER -