Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women: The Ohasama study

Mami Seki, Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Hirohito Metoki, Takuo Hirose, Megumi Tsubota-Utsugi, Kei Asayama, Atsuhiro Kanno, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Objective: Only a few of numerous epidemiological studies have demonstrated a positive association between environmental tobacco smoke (ETS) exposure and blood pressure (BP), despite experimental studies showing such a positive association. The association between home blood pressure (HBP) and ETS exposure was investigated in the general population. Methods: Five hundred and seventy-nine nonsmoking Japanese women were enrolled. The participants were classified into four categories according to their responses to a self-administered questionnaire: unexposed women (non-ETS), women exposed at home [ETS(home)], at the workplace/other places [ETS(work/other)] and at home and at the workplace/other places [ETS(both)]. Variables were compared using analysis of covariance adjusted for age, marital status, body mass index, diabetes mellitus, stroke, heart disease, hyperlipidemia, alcohol intake, salt intake and activity levels. Results: In participants without antihypertensive medication, systolic morning HBP in ETS(both) was 4 mmHg higher than that in non-ETS (116.8 ± 1.01 vs. 113.1 ± 1.08 mmHg, P = 0.02) and systolic morning HBP in ETS(home) and systolic evening HBP in ETS(both) were 3 mmHg higher than those in non-ETS (116.2 ± 1.07 vs. 113.1 ± 1.08 mmHg, P = 0.04; and 115.3 ± 1.02 vs. 111.9 ± 1.09 mmHg, P = 0.03, respectively). In participants with antihypertensive medication, ETS exposure status was not significantly associated with increased HBP levels. Conclusions: A positive association between HBP levels and ETS exposure was confirmed. HBP measurement is recommended in population-based studies investigating the effects of ETS exposure. ETS exposure may increase BP, thereby synergistically contributing to unfavorable cardiovascular outcomes along with other deleterious effects of ETS.

Original languageEnglish
Pages (from-to)1814-1820
Number of pages7
JournalJournal of hypertension
Issue number9
Publication statusPublished - 2010 Sept
Externally publishedYes


  • blood pressure
  • blood pressure monitoring ambulatory
  • cardiovascular diseases
  • home blood pressure monitoring
  • particulate matter
  • passive smoking

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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