Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men

Aiman El-Saed, Akira Sekikawa, Riad Wahid Zaky, Takashi Kadowaki, Tomoko Takamiya, Tomonori Okamura, Daniel Edmundowicz, Yoshikuni Kita, Lewis H. Kuller, Hirotsugu Ueshima

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15 Citations (Scopus)


Background: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations. Methods: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002. Results: Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels. Conclusion: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalJournal of epidemiology
Issue number6
Publication statusPublished - 2007 Dec 19
Externally publishedYes


  • 1-Alkyl-2-acetylglycerophosphocholine esterase
  • Asian continental ancestry group
  • Atherosclerosis
  • Calcification
  • Coronary arteriosclerosis
  • European Continental Ancestry Group

ASJC Scopus subject areas

  • Epidemiology


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