TY - JOUR
T1 - Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese
AU - Ohshige, Toshihiko
AU - Iwata, Minoru
AU - Omori, Shintaro
AU - Tanaka, Yasushi
AU - Hirose, Hiroshi
AU - Kaku, Kohei
AU - Maegawa, Hiroshi
AU - Watada, Hirotaka
AU - Kashiwagi, Atsunori
AU - Kawamori, Ryuzo
AU - Tobe, Kazuyuki
AU - Kadowaki, Takashi
AU - Nakamura, Yusuke
AU - Maeda, Shiro
PY - 2011
Y1 - 2011
N2 - Background: Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies. Methodology/Principal Findings: We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05). Conclusions: These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities.
AB - Background: Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies. Methodology/Principal Findings: We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05). Conclusions: These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities.
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U2 - 10.1371/journal.pone.0026911
DO - 10.1371/journal.pone.0026911
M3 - Article
C2 - 22046406
AN - SCOPUS:80055035412
SN - 1932-6203
VL - 6
JO - PloS one
JF - PloS one
IS - 10
M1 - e26911
ER -
