TY - JOUR
T1 - Association of ras p21 with differentiation of epidermal keratinocytes in proliferating skin diseases
AU - Kikuchi, Arata
AU - Amagai, Masayuki
AU - Nishikawa, Takeji
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/9
Y1 - 1992/9
N2 - We examined the localization of DNA replicating cells and ras oncogene product p21 positive cells in proliferating skin diseases, such as psoriasis vulgaris, lichen planus, verruca vulgaris, verruca plana juvenilis and seborrheic keratosis. ras p21-positive cells were found rather in the differentiated layers than in the proliferating layers of the epidermis. We indicate that the expression of ras p21 can be associated with the differentiation of epidermal keratinocytes not only in tumor tissues but also in inflammatory skin diseases.
AB - We examined the localization of DNA replicating cells and ras oncogene product p21 positive cells in proliferating skin diseases, such as psoriasis vulgaris, lichen planus, verruca vulgaris, verruca plana juvenilis and seborrheic keratosis. ras p21-positive cells were found rather in the differentiated layers than in the proliferating layers of the epidermis. We indicate that the expression of ras p21 can be associated with the differentiation of epidermal keratinocytes not only in tumor tissues but also in inflammatory skin diseases.
KW - DNA replicating cell
KW - Differentiation
KW - Proliferating skin disease
KW - ras p21
UR - http://www.scopus.com/inward/record.url?scp=0027053646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027053646&partnerID=8YFLogxK
U2 - 10.1016/0923-1811(92)90063-H
DO - 10.1016/0923-1811(92)90063-H
M3 - Article
C2 - 1419983
AN - SCOPUS:0027053646
SN - 0923-1811
VL - 4
SP - 83
EP - 86
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
IS - 2
ER -