TY - JOUR
T1 - Asthma is a risk factor for general fatigue of long COVID in Japanese nation-wide cohort study
AU - Sunata, Keeya
AU - Miyata, Jun
AU - Terai, Hideki
AU - Matsuyama, Emiko
AU - Watase, Mayuko
AU - Namkoong, Ho
AU - Asakura, Takanori
AU - Masaki, Katsunori
AU - Chubachi, Shotaro
AU - Ohgino, Keiko
AU - Kawada, Ichiro
AU - Harada, Norihiro
AU - Sasano, Hitoshi
AU - Nakamura, Ai
AU - Kusaka, Yu
AU - Ohba, Takehiko
AU - Nakano, Yasushi
AU - Nishio, Kazumi
AU - Nakajima, Yukiko
AU - Suzuki, Shoji
AU - Yoshida, Shuichi
AU - Tateno, Hiroki
AU - Ishii, Makoto
AU - Fukunaga, Koichi
N1 - Publisher Copyright:
© 2023 Japanese Society of Allergology
PY - 2024/4
Y1 - 2024/4
N2 - Background: Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue is frequently observed in patients with long COVID during acute and post-acute phases. This study aimed to identify the specific risk factors for general fatigue in long COVID. Methods: Hospitalized patients with COVID-19 aged over 18 years were enrolled in a multicenter cohort study at 26 medical institutions. Clinical data during hospitalization and patient-reported outcomes after discharge were collected from medical records, paper-based questionnaires, and smartphone apps. Results: Among prolonged symptoms through 1-year follow-ups, general fatigue was the most interfering symptom in daily life. Patients with protracted fatigue at all follow-up periods had lower quality of life scores at the 12-month follow-up. Univariate logistic regression analysis of the presence or absence of general fatigue at the 3-month, 6-month, and 12-month follow-ups identified asthma, younger age, and female sex as risk factors for prolonged fatigue. Multivariable logistic regression analysis revealed that asthma was an independent risk factor for persistent fatigue during the 12-month follow-up period. Longitudinal changes in the symptoms of patients with or without asthma demonstrated that general fatigue, not cough and dyspnea, was significantly prolonged in patients with asthma. Conclusions: In a Japanese population with long COVID, prolonged general fatigue was closely linked to asthma. A preventive approach against COVID-19 is necessary to avoid sustained fatigue and minimize social and economic losses in patients with asthma.
AB - Background: Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue is frequently observed in patients with long COVID during acute and post-acute phases. This study aimed to identify the specific risk factors for general fatigue in long COVID. Methods: Hospitalized patients with COVID-19 aged over 18 years were enrolled in a multicenter cohort study at 26 medical institutions. Clinical data during hospitalization and patient-reported outcomes after discharge were collected from medical records, paper-based questionnaires, and smartphone apps. Results: Among prolonged symptoms through 1-year follow-ups, general fatigue was the most interfering symptom in daily life. Patients with protracted fatigue at all follow-up periods had lower quality of life scores at the 12-month follow-up. Univariate logistic regression analysis of the presence or absence of general fatigue at the 3-month, 6-month, and 12-month follow-ups identified asthma, younger age, and female sex as risk factors for prolonged fatigue. Multivariable logistic regression analysis revealed that asthma was an independent risk factor for persistent fatigue during the 12-month follow-up period. Longitudinal changes in the symptoms of patients with or without asthma demonstrated that general fatigue, not cough and dyspnea, was significantly prolonged in patients with asthma. Conclusions: In a Japanese population with long COVID, prolonged general fatigue was closely linked to asthma. A preventive approach against COVID-19 is necessary to avoid sustained fatigue and minimize social and economic losses in patients with asthma.
KW - Asthma
KW - Female
KW - General fatigue
KW - Japanese cohort study
KW - Long COVID-19
UR - http://www.scopus.com/inward/record.url?scp=85178240116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178240116&partnerID=8YFLogxK
U2 - 10.1016/j.alit.2023.11.003
DO - 10.1016/j.alit.2023.11.003
M3 - Article
C2 - 37996384
AN - SCOPUS:85178240116
SN - 1323-8930
VL - 73
SP - 206
EP - 213
JO - Allergology International
JF - Allergology International
IS - 2
ER -