Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

Masahiro Yokoyama; Takeshi Sugai; Hiromichi Ohta

doi:10.1016/S0957-4166(00)80214-1

Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

Masahiro Yokoyama, Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

Original language	English
Pages (from-to)	1081-1084
Number of pages	4
Journal	Tetrahedron: Asymmetry
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/S0957-4166(00)80214-1
Publication status	Published - 1993 Jun

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/S0957-4166(00)80214-1

Cite this

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title = "Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism",

abstract = "Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.",

author = "Masahiro Yokoyama and Takeshi Sugai and Hiromichi Ohta",

year = "1993",

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AU - Yokoyama, Masahiro

AU - Sugai, Takeshi

AU - Ohta, Hiromichi

PY - 1993/6

Y1 - 1993/6

N2 - Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

AB - Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

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DO - 10.1016/S0957-4166(00)80214-1

M3 - Article

AN - SCOPUS:0027280573

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JO - Tetrahedron: Asymmetry

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ER -

Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

Abstract

ASJC Scopus subject areas

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