Asymmetric hydrolysis of l-Cyanoalkyl acetates

Hiromichi Ohta, Satoshi Hiraga, Kenji Miyamoto, Gen Ichi Tsuchihashi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Microorganisms that enantioselectively hydrolyze I-cyanoalkyl acetates (aldehyde cyanohydrin) were screened. Candida tropicalis was found to be the best. The enzyme system of this strain catalyzed the enantioselective hydrolysis of (S)-isomers, leaving behind the (R)-acetates. The optical purities of recovered acetates were high as measured by IH-NMR analysis in the presence of a chiral shift reagent.

Original languageEnglish
Pages (from-to)3023-3027
Number of pages5
JournalAgricultural and biological chemistry
Issue number12
Publication statusPublished - 1988 Dec

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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