TY - JOUR
T1 - Atrial natriuretic peptide secretion in rabbits with aortic regurgitation
AU - Wainai, Y.
AU - Kusuhara, M.
AU - Yamada, T.
AU - Yoshikawa, T.
AU - Suzuki, M.
AU - Hori, S.
AU - Handa, S.
AU - Yoshinaga, K.
AU - Yamaguchi, K.
PY - 1990/12
Y1 - 1990/12
N2 - We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive (IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.
AB - We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive (IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.
KW - Aortic valve insufficiency
KW - Heart failure, congestive
KW - Natriuretic peptides, atrial
KW - Rabbits
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U2 - 10.1007/PL00020001
DO - 10.1007/PL00020001
M3 - Article
C2 - 2138349
AN - SCOPUS:0025190649
SN - 0300-9130
VL - 190
SP - 13
EP - 18
JO - Research in Experimental Medicine
JF - Research in Experimental Medicine
IS - 1
ER -